Injury guide

Depo Shot and Brain Tumor Questions

Have a meningioma after the Depo shot? It is a tumor in tissue around the brain or spine.

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Updated Oct 4, 202617 sources

This may apply to you if

  • Have your shot name and dates ready for a lawyer to review.
  • Have the report that names your meningioma, a tumor in tissue around the brain.
  • If you already have a lawyer, ask whether your claim is eligible for the reported program.

What the public record says

These are cited sources. Their inclusion does not imply that they endorse People’s Justice or reviewed this page.

M. Casey Rodgers · U.S. District Court, Northern District of Florida · United States District Judge

Finding: The August 10, 2026 order describes an agreement for many existing federal claims and separate court procedures for continuing litigation. Ask a lawyer which track applies to you.

Case Management Order No. 14 (opens in a new tab) · Aug 10, 2026 · Checked Oct 3, 2026

Noémie Roland · EPI-PHARE, French National Agency for Medicines and Health Products Safety and French National Health Insurance · First-listed study author

Finding: The 2024 BMJ study found an association between injectable medroxyprogesterone use and meningioma surgery in French health records. A small exposed group and observational design limit what it can show about an individual.

Use of progestogens and the risk of intracranial meningioma: national case-control study (opens in a new tab) · Mar 27, 2024 · Checked Oct 3, 2026

The evidence and its limits

EPI-PHARE · BMJ · 2024

French health-record study of hormone medicines and meningioma surgery

Design:
Case-control
Participants:
108,366 women: 18,061 surgery cases and 90,305 matched controls
Finding:
Injectable medroxyprogesterone acetate use was associated with higher odds of surgery for meningioma; the excess was linked to prolonged use.
Main limitation
Observational French data; only nine exposed cases and eleven exposed controls for this injection. The study does not prove that the shot caused any one person’s tumor or define who qualifies for a claim.

Read the source: French health-record study of hormone medicines and meningioma surgery (opens in a new tab) · Checked Oct 3, 2026

National Health Service (UK) · 2025

NHS patient care guidance, reviewed February 2025

Design:
Other study design
Participants:
Not applicable: public patient guidance, not a study sample
Finding:
The guidance describes symptom assessment and when to seek medical help for possible brain-tumor symptoms.
Main limitation
General UK care guidance; not a Depo causation study, personal diagnosis, MRI screening rule or US service guarantee.

Read the source: NHS patient care guidance, reviewed February 2025 (opens in a new tab) · Checked Oct 3, 2026

The short answer

What is a meningioma?
A meningioma is a tumor in the tissue around the brain or spinal cord. Ask your care team what your report says about its type and grade. [4]
What signs should I discuss with a doctor?
Tell the care team about new or changing symptoms. A symptom list cannot confirm that you have a tumor or that the shot caused it. [17]
How is the tumor diagnosed and treated?
Ask the care team to explain your scan and any tissue test. The care plan must fit the tumor and your health; it is not a step chosen to improve a claim. [4]
What does the research say about the shot?
A French study found a link between the shot and surgery for this tumor. It does not prove the cause in one person. It does not decide a payment. [9]

What rules a case out

Not covered by this case

  • Symptoms or shot use alone do not prove a meningioma claim.
  • A study association does not establish the cause of your own tumor.
  • Care guidance does not set universal scan, program or firm acceptance rules.

The process

What happens next

  1. 01

    You answer a few questions

    About two minutes. Nothing is sent until you agree on the last step and press submit.

  2. 02

    A lawyer looks at it

    A lawyer at the firm reads your answers and checks them against the current case criteria.

  3. 03

    The firm decides and gets in touch

    If the firm takes your case, you get the terms in writing to read before you sign. You can always say no.

Neurologist or primary-care doctor talking with a woman patient, reviewing results together
Photo illustration.

When it fits this case

  • Have your shot name and dates ready for a lawyer to review.
  • Have the report that names your meningioma, a tumor in tissue around the brain.
  • If you already have a lawyer, ask whether your claim is eligible for the reported program.

Have a meningioma after the Depo shot? It is a tumor in tissue around the brain or spine. Ask your care team about the diagnosis and a lawyer about your records and claim options.

What is a meningioma?

A meningioma is a tumor in the tissue around the brain or spinal cord. Ask your care team what your report says about its type and grade.

The National Cancer Institute describes three grades of this tumor. Grade 1 tends to grow slowly; grade 3 is cancerous and grows fast. Grade describes the cells, not whether a legal claim is accepted.

Keep the exact diagnosis in your own records. Ask whether the report says meningioma or another type of tumor. If the name is unclear, ask the doctor to explain it before selecting a diagnosis on a legal form.

What signs should I discuss with a doctor?

Tell the care team about new or changing symptoms. A symptom list cannot confirm that you have a tumor or that the shot caused it.

NHS guidance on non-cancerous brain tumors lists changes in vision, headaches and seizures among possible signs. The signs depend on the part of the brain affected. This is general guidance, not a diagnosis for a Depo user.

Describe what changed, when it started and how it affects daily tasks. Say whether the symptoms existed before the shot. Ask what needs prompt care and whom to contact if it changes while you wait.

How is the tumor diagnosed and treated?

Ask the care team to explain your scan and any tissue test. The care plan must fit the tumor and your health; it is not a step chosen to improve a claim.

NCI describes tissue review, when surgery is possible, to help establish a diagnosis and grade. Its treatment discussion focuses on higher-grade tumors. Do not treat that discussion as a plan for every meningioma.

Ask why the team proposes treatment or follow-up, what the goal is and when the next visit should occur. Have it explain words such as grade and any part of the report that is uncertain. Keep those answers with your care records.

What does the research say about the shot?

A French study found a link between the shot and surgery for this tumor. It does not prove the cause in one person. It does not decide a payment.

The study compared women who had surgery with women who did not. For injectable medroxyprogesterone, only nine cases and eleven controls had exposure. Those small groups and the study design limit how the finding applies to a person.

The FDA label reports meningiomas after repeated use, mainly long-term use. It tells clinicians to monitor signs and to stop Depo-Provera CI if meningioma is diagnosed. Bring medication questions to your treating clinician.

Who should ask about a Depo-Provera claim?

Used the shot and have this tumor? Ask a lawyer to check your shot and health records. A study or diagnosis alone does not mean a firm will take your case.

The federal cases allege tumors called meningiomas inside the skull after use of branded or generic products. The court also describes a program for many existing claims and a separate route for continuing litigation. These are not guarantees for every person with a tumor.

Ask which product, diagnosis, dates and law matter for your situation. Give the lawyer any prior case or signed agreement. Request a personal deadline check; a program date is not every reader’s time limit to sue.

What records help with care and a claim review?

Gather your shot dates and the reports you have. Ask the care team how to request missing health records. Keep a copy of each request.

Useful preparation can include the scan report, tissue report if one exists, visit notes and product name. Mark a missing date or uncertain detail rather than guessing. Ask the doctor which record describes the diagnosis and the lawyer which records the claim needs.

Federal access rules cover certain medical records, with exceptions. They do not certify this site’s privacy. Before sharing a full file or hiring a lawyer, ask about data use, written fees, expenses and what you could owe without a recovery.

Scientific evidence for this case

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Questions about this guide

Are all meningiomas from Depo-Provera cancerous?

No. The National Cancer Institute says grade 1 meningiomas are the most common and grow slowly, while grade 3 meningiomas are malignant. A diagnosis, grade, and treatment plan should come from your medical team, not a claim page.

Source: National Cancer Institute: Meningioma · as of Oct 7, 2026

Can a meningioma shrink if I stop Depo-Provera?

It depends. Ask your treating clinician about symptoms, testing, or medication changes. The FDA label says to monitor for signs and symptoms of meningioma and to discontinue Depo-Provera CI if a meningioma is diagnosed. A claim page cannot diagnose you or decide your medical care.

Source: FDA Depo-Provera CI label, revised December 2025 · as of Oct 7, 2026

How long after stopping Depo-Provera can a meningioma appear?

Meningiomas are slow-growing tumors that may take years to reach detectable size. A meningioma could be diagnosed months or even years after the last Depo-Provera injection. The key factor is cumulative MPA exposure over the total period of use, not when the last injection occurred.

Sources

  1. Court order 14: settlement and ongoing casesCourt order 14: settlement and ongoing cases · court
  2. JPML pending cases report, October 1, 2026JPML pending cases report, October 1, 2026 · court
  3. FDA Depo-Provera CI label, December 2025FDA Depo-Provera CI label, December 2025 · regulator
  4. National Cancer Institute: meningiomaNational Cancer Institute: meningioma · regulator
  5. ABA Model Rule 1.5: feesABA Model Rule 1.5: fees
  6. Medical record access: 45 CFR 164.524Medical record access: 45 CFR 164.524 · regulator
  7. SDNY court guide: filing time limitsSDNY court guide: filing time limits · court
  8. Court common-benefit fee order 2Court common-benefit fee order 2 · court
  9. BMJ 2024 original author abstract via PubMedBMJ 2024 original author abstract via PubMed · study
  10. Medroxyprogesterone Acetate and Meningioma: A Global IssueFrontiers in Global Womens Health · 2025 · study
  11. Use of High-Dose Medroxyprogesterone Acetate and Risk of Intracranial MeningiomaThe BMJ · 2024 · study
  12. The Association between Medroxyprogesterone Acetate Exposure and MeningiomaCancers · 2024 · study
  13. Pfizer Reaches Agreement in Principle to Resolve Federal Depo-Provera MDLlaw360.com · Jun 15, 2026 · court
  14. JAMA Network Open Study Reports 4.5x Meningioma Risk with Medroxyprogesteronepubmed.ncbi.nlm.nih.gov · Jul 1, 2026 · study
  15. On June 15, 2026, MDL 3140 (N.D. Fla.) Leadership Counsel announced a settlement with the Pfizer defendants of a majority of the claims in the MDL and New York state court over Depo-Provera meningioma claims (Case Management Order No. 12, filed July 27, 2026). Financial terms NOT disclosed; eligibility and compensation amounts not released; deal pending finalization at the time (Case Management Order No. 14, filed Aug. 10, 2026, later described a settlement agreement dated July 22, 2026 and states no compensation amounts). The JPML reported 5,830 actions pending in MDL 3140 on July 1, 2026 and 6,412 on October 1, 2026.flnd.uscourts.gov · Jun 15, 2026 · court
  16. Settlement in principle announced; docket had grown +1,739 filings (+46%) in the single preceding month — the leading-indicator pattern.jpml.uscourts.gov · Jun 15, 2026 · court
  17. NHS: non-cancerous brain tumor guidance

Checked against 15 primary sources by People's Justice editors · Updated

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