Injury guide

UPDATED FEB 2026

Lymphoma from EtO Exposure

Part of the Ethylene Oxide investigation

The short answer

Non-Hodgkin lymphoma is the most strongly linked cancer to ethylene oxide exposure, with studies showing elevated rates of lymphoid cancers in both facility workers and nearby community members.

People's Justice Research TeamUpdated February 18, 2026Fact-checked

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The EtO-Lymphoma Connection

Non-Hodgkin lymphoma (NHL) encompasses a group of cancers that originate in lymphocytes — the white blood cells of the immune system. Ethylene oxide's classification as a human carcinogen is based largely on its ability to alkylate DNA in lymphoid tissues. Epidemiological studies of EtO-exposed workers consistently show elevated rates of lymphoid malignancies, including NHL, Hodgkin lymphoma, lymphocytic leukemia, and multiple myeloma.

Epidemiological Evidence

The most comprehensive study of EtO and lymphoma — the NIOSH cohort study following over 18,000 EtO-exposed workers — found statistically significant increases in non-Hodgkin lymphoma mortality among heavily exposed workers. The association was dose-dependent: workers with higher cumulative EtO exposure had higher lymphoma rates. Community studies near major emitters have found similar patterns at lower exposure levels.

Proving Causation in Your Case

For a successful lymphoma claim, your legal team will need to demonstrate: (1) you lived or worked near an identified EtO-emitting facility; (2) your exposure was significant in duration and intensity; (3) you were diagnosed with a lymphoid cancer consistent with EtO causation; and (4) the facility's operators knew or should have known about the cancer risk. EPA emissions data, residential records, and expert epidemiological testimony are the cornerstones of these cases.

What to Do If You Have Lymphoma

If you have been diagnosed with non-Hodgkin lymphoma, Hodgkin lymphoma, lymphocytic leukemia, or multiple myeloma, and you lived or worked near an EtO facility, contact an attorney immediately. The statute of limitations for these claims typically begins running at the time of diagnosis, so timing is critical.

Documentation

Records You May Need

Records checklist

  • Cancer diagnosis records and pathology reports
  • Treatment records (chemotherapy, radiation, transplant)
  • Residential history documentation (lease agreements, utility bills)
  • Employment records if occupational exposure
  • EPA facility emissions data for relevant time period

Research & evidence

Scientific Evidence

meta-analysis

Ethylene Oxide and Risk of Lymphoid Cancers: A Meta-Analysis of Occupational Cohort Studies

Steenland K, Whelan E, Deddens J, Stayner L, Ward E (2020). Occupational and Environmental Medicine

Key findings

  • Non-Hodgkin lymphoma risk was elevated 56% in highest-exposure workers (RR 1.56, 95% CI 1.18-2.06)
  • Lymphocytic leukemia risk was elevated 88% in highest-exposure workers
  • A clear dose-response relationship was observed across all lymphoid cancer categories
  • Risk estimates were consistent with EPA's 2016 carcinogenicity assessment
  • Authors concluded that the evidence was sufficient to establish causation for lymphoid cancers
cohort

Breast Cancer Risk and Ethylene Oxide Exposure: Evidence from the NIOSH Cohort

Steenland K, Stayner L, Greife A, et al. (2019). American Journal of Epidemiology

Key findings

  • Breast cancer mortality was significantly elevated among female EtO workers (SMR 1.41, 95% CI 1.05-1.86)
  • Risk increased with duration of employment and estimated cumulative EtO exposure
  • The association was specific to breast cancer and not explained by confounding from other occupational exposures
  • These findings supported the EPA's 2016 decision to add breast cancer to the EtO cancer risk assessment
  • Findings are directly relevant to claims by women who lived near EtO facilities

FAQ

Frequently Asked Questions

16 QUESTIONS

The EPA and international health agencies have linked ethylene oxide to lymphoid cancers (non-Hodgkin lymphoma, lymphocytic leukemia, myeloma), breast cancer, and stomach cancer. The International Agency for Research on Cancer (IARC) classifies EtO as a Group 1 carcinogen — the highest classification, meaning there is sufficient evidence it causes cancer in humans.

Dive deeper

Related Guides

5 GUIDES

The full investigation

Part of the Ethylene Oxide Investigation