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Current Promising Clinical Trials for Mesothelioma
Active areas of mesothelioma clinical research include: CAR-T cell therapy targeting mesothelin (MESO-CAR-T trials at Penn Medicine and NCI), which engineers the patient's own immune T-cells to recognize and kill mesothelioma cells expressing the mesothelin protein; tumor-treating fields (TTFields) using the Optune device, which delivers continuous low-intensity electric fields to disrupt cancer cell division — Phase III STELLAR trial showed median OS improvement; anti-mesothelin antibody-drug conjugates (anetumab ravtansine) combining tumor-targeting with direct cytotoxic payload delivery; and combination immunotherapy trials pairing existing checkpoint inhibitors with novel agents targeting TIM-3, LAG-3, and TIGIT immune checkpoints.
How to Find and Join a Clinical Trial
Patients can search for active mesothelioma clinical trials at ClinicalTrials.gov (National Institutes of Health trial registry) by searching for "mesothelioma" with filters for location, phase, and treatment type. Specialized mesothelioma centers running the highest volume of trials include: Memorial Sloan Kettering Cancer Center (New York), MD Anderson Cancer Center (Houston), Penn Medicine Abramson Cancer Center (Philadelphia), Brigham and Women's Hospital / Dana-Farber Cancer Institute (Boston), and University of Chicago Medicine. A mesothelioma specialist (thoracic oncologist) at these centers can evaluate trial eligibility and coordinate enrollment. Clinical trial participation does not affect legal claims — compensation from trust funds and lawsuits is fully available to patients regardless of trial enrollment.
Key data
Data & Statistics
100+ active mesothelioma clinical trials open for enrollment as of 2026
ClinicalTrials.gov — NIH
STELLAR trial: TTFields + chemotherapy improved median OS by 2.2 months vs chemo alone
Journal of Clinical Oncology 2021
FAQ
Frequently Asked Questions
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Related Guides
- Pleural MesotheliomaPleural mesothelioma is the most common form of asbestos cancer, accounting for 75% of diagnoses. It develops in the lining of the lungs and is staged I-IV, with Stage I/II amenable to surgery and Stage III/IV managed with chemotherapy and immunotherapy. Average settlements exceed $1 million.
- Mesothelioma VA ClaimsVeterans with mesothelioma from service-connected asbestos exposure qualify for VA disability compensation (up to $3,737/month tax-free), free VA healthcare, Aid and Attendance, and Dependency and Indemnity Compensation for surviving family members. VA claims do not reduce legal settlements.
- Mesothelioma Settlements — Timeline and AmountsAverage mesothelioma settlements range from $1 million to $2.4 million combining trust fund distributions and civil settlements. Trust fund claims typically resolve in 6-18 months. Civil settlements often resolve in 12-24 months. Cases that reach trial have produced verdicts from $5 million to $80 million or more.
- Asbestos Products — Common Sources of ExposureAsbestos was incorporated into thousands of commercial products — from pipe insulation and building materials to automotive parts and consumer products. Identifying the specific asbestos products you were exposed to is a critical first step in building a trust fund and litigation strategy.
- Second-Hand Asbestos Exposure — Family Members of WorkersFamily members of asbestos workers who never set foot in a worksite have developed mesothelioma from asbestos fibers brought home on workers' clothing, hair, and skin — called para-occupational or household exposure. These cases have successfully produced multi-million-dollar verdicts.
- Mesothelioma Wrongful Death ClaimsWhen a mesothelioma patient dies before their case is resolved — or before a lawsuit is filed — surviving family members can bring a wrongful death claim. These claims compensate the family for loss of financial support, loss of companionship, grief, and the decedent's own pain and suffering before death.
- Mesothelioma Trial Verdicts — Historic and RecentMesothelioma trial verdicts have reached into the hundreds of millions of dollars, driven by jury outrage over decades of corporate suppression of asbestos hazard knowledge. Even average trial verdicts — in the $10M-$30M range — dwarf typical settlement amounts, giving mesothelioma attorneys leverage in pre-trial negotiations.
- Industrial Plant Asbestos ExposureWorkers in oil refineries, chemical plants, power plants, and steel mills faced pervasive asbestos exposure throughout most of the 20th century through pipe insulation, boiler lagging, high-temperature equipment insulation, and gasket replacement. These industrial settings produced some of the highest cumulative asbestos fiber exposures ever documented.
- Auto Mechanics and Asbestos Brake ExposureAuto mechanics who worked with asbestos-containing brake pads, drum linings, and clutch plates — especially before OSHA wet-brake regulations in the 1990s — were exposed to significant asbestos dust with each brake job. Brake pad manufacturers (Bendix/Honeywell, Raybestos) have substantial trust fund and litigation exposure for mechanic claims.
- Shipyard Asbestos ClaimsShipyard workers — including civilian Navy yard employees, commercial shipbuilders, and ship repair workers — faced extremely high asbestos exposures in confined below-decks work environments. Shipyard claims involve both trust fund defendants (insulation manufacturers) and solvent defendants (valve, pump, and turbine manufacturers with Navy contracts).
- Mesothelioma Statute of Limitations by StateMesothelioma statutes of limitations range from 1 year (Louisiana, Tennessee, Kentucky) to 3 years (Maine, Massachusetts, New Jersey) from the date of diagnosis. In every state, the discovery rule applies — the clock starts at diagnosis, not exposure. Missing this deadline bars your claim permanently. Contact an attorney immediately after diagnosis.
- Peritoneal MesotheliomaPeritoneal mesothelioma — cancer of the abdominal lining — accounts for 20-25% of cases and has a substantially better prognosis than pleural mesothelioma when treated with cytoreductive surgery plus HIPEC, achieving median survival over 5 years in selected patients.
- Asbestos Lung CancerAsbestos is an established cause of lung cancer independent of mesothelioma, and asbestos-exposed smokers face a risk up to 90 times higher than the general population. Asbestos-related lung cancer is separately compensable through trust funds and civil litigation, though claim values are generally lower than mesothelioma.
- Asbestosis DiseaseAsbestosis is a non-cancerous progressive lung fibrosis caused by asbestos exposure. While less severe than mesothelioma, it causes significant respiratory disability and qualifies for asbestos trust fund compensation and disability claims. It also substantially increases the risk of developing mesothelioma or lung cancer.
- Mesothelioma Diagnosis ProcessMesothelioma diagnosis requires CT scan, PET-CT for staging, and tissue biopsy with specialized pathological analysis. Misdiagnosis is common — mesothelioma cells can resemble adenocarcinoma. If you have asbestos exposure history and respiratory or abdominal symptoms, request specialist evaluation at a mesothelioma center.
- Mesothelioma Treatment OptionsMesothelioma treatment has advanced significantly in the past decade. Surgery (EPP or P/D), chemotherapy (pemetrexed/cisplatin), and immunotherapy (nivolumab/ipilimumab) are FDA-approved options. Clinical trials continue to expand the horizon. Specialized mesothelioma centers offer the best outcomes.
- Construction Workers and Asbestos ExposureConstruction workers — particularly insulators, drywall installers, roofers, and floor tile workers — faced some of the highest occupational asbestos exposures in history. Insulators have mesothelioma rates 800 times higher than the general population. Legal claims for construction worker asbestos exposure are among the most well-documented in asbestos litigation.
- Navy Veterans and MesotheliomaNavy veterans account for approximately 30% of all mesothelioma diagnoses in the United States. Asbestos was used throughout U.S. naval vessels — boiler rooms, engine rooms, pipe insulation, turbine insulation, flooring — from WWII through the 1970s. Veterans can pursue VA disability claims plus asbestos trust fund claims and civil litigation simultaneously.
- Asbestos Trust Funds — How They WorkOver $30 billion in asbestos trust funds has been established by more than 60 bankrupt asbestos manufacturers. Filing trust claims does not require a lawsuit and can proceed simultaneously with civil litigation. An experienced mesothelioma attorney identifies all applicable trusts and files simultaneously, often producing $200K-$800K in trust distributions.
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