Injury guide

UPDATED FEB 2026

Ozempic Stomach Paralysis Lawsuit

Part of the Ozempic / GLP-1 investigation

The short answer

Gastroparesis — stomach paralysis — is the primary injury in the GLP-1 MDL. Over 3,000 lawsuits allege that Ozempic and similar drugs cause a potentially permanent condition that was not adequately disclosed.

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What Is Ozempic-Induced Gastroparesis?

Gastroparesis means "stomach paralysis" — a condition where the stomach muscles cannot contract normally to move food through the digestive system. GLP-1 drugs like Ozempic work by dramatically slowing gastric emptying, and in a significant subset of patients this slowing becomes pathological. The result is severe, persistent nausea, vomiting of undigested food, abdominal pain, bloating, and malnutrition.

The Failure-to-Warn Argument

Before January 2025, Ozempic's label did not mention gastroparesis by name. The label described common GI side effects like nausea and vomiting but did not warn that these could represent the onset of a serious, potentially permanent condition. Plaintiffs argue that Novo Nordisk knew or should have known about the gastroparesis risk from clinical trial data showing 82.2% GI adverse event rates.

Is Ozempic Gastroparesis Permanent?

In some patients, gastroparesis resolves after stopping the drug. In others, it persists for months or years. Some patients develop permanent gastroparesis requiring ongoing medical management, tube feeding, or surgical intervention such as gastric electrical stimulator implantation.

The Gastric Emptying Study Requirement

An August 2025 MDL ruling requires gastroparesis plaintiffs to have a properly performed gastric emptying scintigraphy study confirming delayed gastric emptying at the time of diagnosis. If you are experiencing gastroparesis symptoms, obtaining this diagnostic study is critical for both your medical care and any potential legal claim.

Research & evidence

Scientific Evidence

cohort

Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

Hathaway JT, Shah MP, Hathaway DB, et al. (2024). JAMA Ophthalmology

Key findings

  • Type 2 diabetes patients: 8.9% NAION risk on semaglutide vs 1.8% on non-semaglutide medications
  • Weight-loss patients: 6.7% NAION risk vs 0.8% on alternatives
  • Risk was highest in first year of use
  • Findings confirmed by Danish/Norwegian cohort study of 424,000+ patients
  • EMA required European label update; Novo Nordisk has not updated U.S. labels
cohort

Risk of Gastrointestinal Adverse Events Associated With GLP-1 Receptor Agonists for Weight Loss

Sodhi M, Rezaeianzadeh R, Kezouh A, Bhatt M (2023). JAMA

Key findings

  • Gastroparesis hazard ratio: 3.67 (95% CI 1.15-11.90)
  • Bowel obstruction hazard ratio: 4.22 (95% CI 1.02-17.40)
  • Pancreatitis hazard ratio: 9.09 (95% CI 1.25-66.00)
  • Study population was non-diabetic weight-loss patients — directly relevant to majority of MDL plaintiffs
  • Findings were robust across sensitivity analyses
meta-analysis

GLP-1 Receptor Agonists and Gallbladder Disease: A Systematic Review of Randomized Controlled Trials

Multiple authors (systematic review) (2024). Clinical Gastroenterology and Hepatology

Key findings

  • 37% increased relative risk of gallbladder disease across 76 RCTs
  • Risk was more pronounced with higher doses and greater weight loss
  • Rapid weight loss mechanism contributes to gallstone formation
  • Risk increased with duration of GLP-1 agonist use
  • Findings support inclusion of gallbladder disease in GLP-1 litigation claims

FAQ

Frequently Asked Questions

36 QUESTIONS

Over 3,100 lawsuits allege that Novo Nordisk (maker of Ozempic, Wegovy, Rybelsus) and Eli Lilly (maker of Mounjaro, Zepbound) failed to adequately warn patients and doctors about severe side effects including gastroparesis (stomach paralysis), bowel obstruction, pancreatitis, and vision loss (NAION). The cases are consolidated in MDL 3094 in the Eastern District of Pennsylvania.

Dive deeper

Related Guides

7 GUIDES

The full investigation

Part of the Ozempic / GLP-1 Investigation